Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.6
USERS' SCORE
Good
Based on 10 Reviews
8.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Lactoferrin (as Apolactoferrin) 
250 mg

Top Medical Research Studies

9
We explored how enteric lactoferrin (eLF) affects cholesterol levels and atherosclerosis in Microminipigs fed a high-fat and high-cholesterol diet. Over eight weeks, eLF significantly lowered total and low-density lipoprotein (LDL) cholesterol levels, while high-density lipoprotein (HDL) levels remained unchanged. Additionally, eLF helped reduce the formation of atherosclerotic lesions in arteries. This suggests that eLF might support cholesterol metabolism by maintaining homeostasis affected by unhealthy diets. Overall, our findings indicate that eLF has potential benefits for preventing high cholesterol and related cardiovascular issues.
Read More
We explored the impact of lactoferrin (LF) on cholesterol management in rats fed a high-cholesterol diet. By investigating how LF interacts with bile acids, we found that it significantly increased the levels of fecal cholesterol excretion by 22% while simultaneously lowering liver cholesterol by 17%.

This suggests that LF effectively promotes cholesterol elimination from the body through its interactions with bile acids, making it a potential natural treatment for managing high cholesterol.
Read More
9
Lactoferrin reduces liver cholesterol levels
We explored the impact of lactoferrin (LF) on cholesterol levels in a mouse study. Mice on a high-fat, high-cholesterol diet were given water containing LF for eight weeks.

Our findings revealed that LF significantly boosted good cholesterol while slashing harmful liver cholesterol levels. It also enhanced bile acid metabolism, promoting cholesterol excretion.

Overall, LF showed promise in managing cholesterol and improving lipid metabolism, although further studies are needed to understand its full effectiveness in humans.
Read More

Most Useful Reviews

9.5
No side effects
Highly recommend! My ferritin level was at 15, and I tried various iron supplements, which caused stomach issues and led to a maximum ferritin of 42 that quickly decreased after stopping. Lactoferin works on a different principle and contains no iron. It raised my ferritin to 50 within a month without side effects, and my stomach felt fine. I have taken 2 packs, and after about 6 months, my ferritin remains stable! Highly recommend.
Read More
9.5
Improved hemoglobin
These capsules work excellently for my anaemic condition. I noticed significant benefits during my last blood test, as they help retain iron and have greatly improved my haemoglobin count. My doctor prescribed one capsule in the morning and evening for two months alongside iron, and they are easy to swallow and tasteless, demonstrating the high quality of the ingredients.
Read More
9.5
Reduced symptoms
I took colostrum and lactoferrin regularly but ran out during a recent parasite infection, which brought on painful stomach symptoms. After ordering more, the pain and bloating subsided significantly within a few days. I’ve read that parasites feed off excess iron, and lactoferrin helps prevent that. Highly recommend! Jarrow consistently provides high-quality products, and these pills are easy to swallow.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.6
  • All Researches
9
Lactoferrin reduces liver cholesterol levels
We explored the impact of lactoferrin (LF) on cholesterol levels in a mouse study. Mice on a high-fat, high-cholesterol diet were given water containing LF for eight weeks.

Our findings revealed that LF significantly boosted good cholesterol while slashing harmful liver cholesterol levels. It also enhanced bile acid metabolism, promoting cholesterol excretion.

Overall, LF showed promise in managing cholesterol and improving lipid metabolism, although further studies are needed to understand its full effectiveness in humans.
Read More
We investigated the impact of bovine lactoferrin (bLF) on antioxidant activity and cholesterol levels in rats fed a high-cholesterol diet. The study involved 44 rats divided into four groups, including a control and a treatment group receiving bLF.

After four weeks, we observed that bLF treatment significantly lowered LDL cholesterol and total cholesterol while raising HDL cholesterol. Additionally, levels of the harmful 8-isoprostane decreased. Overall, these findings suggest that bLF can help counteract some adverse effects of high cholesterol.
Read More
9
We explored how enteric lactoferrin (eLF) affects cholesterol levels and atherosclerosis in Microminipigs fed a high-fat and high-cholesterol diet. Over eight weeks, eLF significantly lowered total and low-density lipoprotein (LDL) cholesterol levels, while high-density lipoprotein (HDL) levels remained unchanged. Additionally, eLF helped reduce the formation of atherosclerotic lesions in arteries. This suggests that eLF might support cholesterol metabolism by maintaining homeostasis affected by unhealthy diets. Overall, our findings indicate that eLF has potential benefits for preventing high cholesterol and related cardiovascular issues.
Read More
We explored how bovine lactoferrin (bLF) impacts cholesterol levels in rats fed a high-cholesterol diet. In a structured study, male rats were split into groups, with some receiving bLF daily.

After four weeks, we observed that bLF significantly lowered harmful cholesterol levels and improved other markers such as homocysteine and leptin. Additionally, it helped increase beneficial cholesterol levels.

These findings suggest that bLF may be a promising treatment for those struggling with high cholesterol and related issues.
Read More
We explored the impact of lactoferrin (LF) on cholesterol management in rats fed a high-cholesterol diet. By investigating how LF interacts with bile acids, we found that it significantly increased the levels of fecal cholesterol excretion by 22% while simultaneously lowering liver cholesterol by 17%.

This suggests that LF effectively promotes cholesterol elimination from the body through its interactions with bile acids, making it a potential natural treatment for managing high cholesterol.
Read More

User Reviews

USERS' SCORE
Good
Based on 10 Reviews
8.7
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9.5
No side effects
Highly recommend! My ferritin level was at 15, and I tried various iron supplements, which caused stomach issues and led to a maximum ferritin of 42 that quickly decreased after stopping. Lactoferin works on a different principle and contains no iron. It raised my ferritin to 50 within a month without side effects, and my stomach felt fine. I have taken 2 packs, and after about 6 months, my ferritin remains stable! Highly recommend.
Read More
9.5
Improved hemoglobin
These capsules work excellently for my anaemic condition. I noticed significant benefits during my last blood test, as they help retain iron and have greatly improved my haemoglobin count. My doctor prescribed one capsule in the morning and evening for two months alongside iron, and they are easy to swallow and tasteless, demonstrating the high quality of the ingredients.
Read More
9.5
Reduced symptoms
I took colostrum and lactoferrin regularly but ran out during a recent parasite infection, which brought on painful stomach symptoms. After ordering more, the pain and bloating subsided significantly within a few days. I’ve read that parasites feed off excess iron, and lactoferrin helps prevent that. Highly recommend! Jarrow consistently provides high-quality products, and these pills are easy to swallow.
Read More
8.8
Less fatigue
Highly recommend! I’ve been struggling with long COVID, and lactoferrin has been one of the few supplements that has helped in alleviating my fatigue and brain fog.
Read More
8
Improved communication
Excellent! After taking this supplement, my communication skills have improved. My blood test also showed an increase in good cholesterol.
Read More

Frequently Asked Questions

High cholesterol, or hyperlipidemia, is a medical condition characterized by an elevated level of cholesterol in the bloodstream. Cholesterol is a waxy, fat-like substance that’s essential for building healthy cells, but too much of it can lead to serious health issues, including heart disease and stroke. Cholesterol is carried through the blood by lipoproteins, with two main types being low-density lipoprotein (LDL) and high-density lipoprotein (HDL). LDL, often referred to as "bad" cholesterol, can lead to the buildup of plaque in the arteries, while HDL, known as "good" cholesterol, helps carry cholesterol away from the arteries and back to the liver.

Factors contributing to high cholesterol can include poor diet, lack of exercise, obesity, smoking, and genetic predisposition. Regular health screenings are crucial, as high cholesterol often presents no overt symptoms. Maintaining a heart-healthy diet rich in fruits, vegetables, whole grains, and healthy fats, coupled with regular physical activity and avoiding tobacco, can help manage cholesterol levels effectively. In some cases, medications may be necessary to control high cholesterol, so consulting with a healthcare provider is key for tailored advice.

Lactoferrin is a multifaceted protein that plays a critical role in the body's immune response and iron metabolism. Found naturally in human and bovine milk, it is also present in various bodily fluids, including saliva and tears. This glycoprotein is primarily noted for its ability to bind iron, which helps to inhibit the growth of bacteria and pathogens that require iron to thrive, thereby providing an antibacterial effect. Additionally, lactoferrin possesses anti-inflammatory and antioxidant properties, further enhancing its protective role in the body.

Lactoferrin has garnered attention for its potential health benefits beyond immunity. It is often marketed as a dietary supplement, with claims that it can support gut health, enhance iron absorption, and potentially aid in preventing infections. While lactoferrin supplementation shows promise in certain contexts, such as improving iron levels in individuals with iron-deficiency anemia, it's essential to approach these claims with cautious optimism and consult with healthcare professionals before starting any new supplement regimen. Overall, lactoferrin stands out as an important component in both nutrition and immune health.

Based on user reviews, individuals who are taking supplements for high cholesterol typically notice varying results over different time frames. For some, improvements can be seen as quickly as within a month of consistent usage. For example, one user observed an increase in good cholesterol levels after taking the supplement for a short duration, highlighting a positive impact (Read Review). However, others have mentioned that the effects may not be immediately noticeable; in one instance, a user reported no significant change in cholesterol levels after a month of use (Read Review).

It's essential to consider that individual results can greatly depend on factors such as diet, lifestyle, and overall health status. While some users have shared their positive outcomes and recommend the supplement, others have experienced minimal effects, suggesting a personalized approach is best. Therefore, while some may see results within weeks, others might need to continue for a longer period to achieve desired outcomes.

Research suggests that lactoferrin, particularly in its bovine form, may offer promising benefits for managing high cholesterol levels. A study found that bovine lactoferrin (bLF) significantly lowered LDL (bad cholesterol) and total cholesterol while increasing HDL (good cholesterol) in rats fed a high-cholesterol diet [2]. Furthermore, another investigation indicated that bLF also lowered harmful cholesterol levels and improved markers related to lipid metabolism [3]. These findings point to bLF as a potential supplement for those looking to combat high cholesterol.

Additionally, lactoferrin has displayed efficacy in promoting cholesterol excretion and managing cholesterol levels through its interaction with bile acids [4]. Similar results were observed in studies involving enteric lactoferrin (eLF) which reported significant reductions in total and LDL cholesterol when administered to Microminipigs on a high-fat diet [5]. Collectively, these studies underscore the potential of lactoferrin, both in bovine and enteric forms, as a supportive measure for cholesterol management, although more research is necessary to fully establish its effectiveness in human subjects.

Based on user reviews, many individuals have reported positive improvements in their symptoms after incorporating lactoferrin into their supplement routines. For instance, one user noted a remarkable rise in their ferritin levels from 15 to 50 within a month, accompanied by no stomach issues, highlighting the supplement’s effectiveness (Read Review). Another reviewer experienced significant benefits related to their anemia, reporting an increase in hemoglobin count after just two months of use (Read Review). These outcomes suggest that lactoferrin may help manage iron levels and support overall health.

Additionally, users have shared relief from gastrointestinal discomfort, with one individual mentioning a reduction in pain and bloating caused by a parasite infection after resuming supplement intake (Read Review). Another user dealing with persistent fatigue from long COVID found alleviation of symptoms, including brain fog, after consistent lactoferrin use (Read Review). While these anecdotes reflect favorable responses to lactoferrin, individual results can vary greatly depending on personal health conditions and lifestyles. Users should consider these factors when assessing whether this supplement may be right for them.

Based on user reviews, there are mixed reports regarding the effectiveness of combining this supplement with other products for managing high cholesterol. One user shared that after using the supplement, their blood test showed an increase in good cholesterol levels, indicating a positive outcome from their supplementation routine (Read Review). In contrast, another user noted a lack of significant change in their cholesterol levels despite using the supplement, suggesting that results may vary based on individual circumstances (Read Review).

Additionally, some users have reported taking this supplement alongside other supportive supplements, like iron and copper, to enhance absorption and overall effectiveness. For example, one user discussed their experience of integrating lactoferrin into an iron-boosting regimen, which resulted in improved ferritin levels and energy (Read Review). These varied experiences highlight that while some may benefit from combining this supplement with other products, individual results can greatly differ, emphasizing the importance of a personalized approach to supplement regimens.

Based on user reviews, there is no definitive consensus on the optimal dose of Lactoferrin specifically for treating high cholesterol. A review mentions that while the user experienced a decrease in very high ferritin levels, they did not report any significant impact on cholesterol levels, noting, "I purchased this here as it was cheaper than the Japanese version. However, I am uncertain about its effects, as my cholesterol levels remain high following the assessment" (Read Review).

Another review indicated that the user observed an increase in good cholesterol levels after taking Lactoferrin, but did not specify a dosage or duration of use. They stated, "My blood test also showed an increase in good cholesterol" (Read Review). Overall, users seem to report benefits in related health areas, but specific recommendations for the right dose for cholesterol management are absent from the reviews provided, suggesting a need for further research.

4.8
No positive effect
I purchased this here as it was cheaper than the Japanese version. However, I am uncertain about its effects, as my cholesterol levels remain high following the assessment. I don't think I will purchase it again.
9.5
No side effects
Highly recommend! My ferritin level was at 15, and I tried various iron supplements, which caused stomach issues and led to a maximum ferritin of 42 that quickly decreased after stopping. Lactoferin works on a different principle and contains no iron. It raised my ferritin to 50 within a month without side effects, and my stomach felt fine. I have taken 2 packs, and after about 6 months, my ferritin remains stable! Highly recommend.
9.5
Improved hemoglobin
These capsules work excellently for my anaemic condition. I noticed significant benefits during my last blood test, as they help retain iron and have greatly improved my haemoglobin count. My doctor prescribed one capsule in the morning and evening for two months alongside iron, and they are easy to swallow and tasteless, demonstrating the high quality of the ingredients.
9.5
Reduced symptoms
I took colostrum and lactoferrin regularly but ran out during a recent parasite infection, which brought on painful stomach symptoms. After ordering more, the pain and bloating subsided significantly within a few days. I’ve read that parasites feed off excess iron, and lactoferrin helps prevent that. Highly recommend! Jarrow consistently provides high-quality products, and these pills are easy to swallow.
8.8
Less fatigue
Highly recommend! I’ve been struggling with long COVID, and lactoferrin has been one of the few supplements that has helped in alleviating my fatigue and brain fog.
8
Improved communication
Excellent! After taking this supplement, my communication skills have improved. My blood test also showed an increase in good cholesterol.
8.8
Boosted energy
This additive is quite significant—though pricey, it's well worth it. I purchased it for an iron-boosting programme, taking it with iron and copper for better absorption. I suffer from low iron and feel immediate weakness when levels drop. I constantly follow programmes to enhance iron and accumulate ferritin reserves. My tests show a steady increase in ferritin, my health has improved, and I've regained energy.
We investigated the impact of bovine lactoferrin (bLF) on antioxidant activity and cholesterol levels in rats fed a high-cholesterol diet. The study involved 44 rats divided into four groups, including a control and a treatment group receiving bLF.

After four weeks, we observed that bLF treatment significantly lowered LDL cholesterol and total cholesterol while raising HDL cholesterol. Additionally, levels of the harmful 8-isoprostane decreased. Overall, these findings suggest that bLF can help counteract some adverse effects of high cholesterol.
We explored how bovine lactoferrin (bLF) impacts cholesterol levels in rats fed a high-cholesterol diet. In a structured study, male rats were split into groups, with some receiving bLF daily.

After four weeks, we observed that bLF significantly lowered harmful cholesterol levels and improved other markers such as homocysteine and leptin. Additionally, it helped increase beneficial cholesterol levels.

These findings suggest that bLF may be a promising treatment for those struggling with high cholesterol and related issues.
We explored the impact of lactoferrin (LF) on cholesterol management in rats fed a high-cholesterol diet. By investigating how LF interacts with bile acids, we found that it significantly increased the levels of fecal cholesterol excretion by 22% while simultaneously lowering liver cholesterol by 17%.

This suggests that LF effectively promotes cholesterol elimination from the body through its interactions with bile acids, making it a potential natural treatment for managing high cholesterol.
9
We explored how enteric lactoferrin (eLF) affects cholesterol levels and atherosclerosis in Microminipigs fed a high-fat and high-cholesterol diet. Over eight weeks, eLF significantly lowered total and low-density lipoprotein (LDL) cholesterol levels, while high-density lipoprotein (HDL) levels remained unchanged. Additionally, eLF helped reduce the formation of atherosclerotic lesions in arteries. This suggests that eLF might support cholesterol metabolism by maintaining homeostasis affected by unhealthy diets. Overall, our findings indicate that eLF has potential benefits for preventing high cholesterol and related cardiovascular issues.

References

  1. Ling CJ, Xu JY, Li YH, Tong X, Yang HH, et al. Lactoferrin promotes bile acid metabolism and reduces hepatic cholesterol deposition by inhibiting the farnesoid X receptor (FXR)-mediated enterohepatic axis. Food Funct. 2019;10:7299. doi:10.1039/c9fo01616c
  2. Faridvand Y, Nozari S, Asoudeh-Fard A, Karimi MA, Pezeshkian M, et al. Bovine lactoferrin ameliorates antioxidant esterase activity and 8-isoprostane levels in high-cholesterol-diet fed rats. Int J Vitam Nutr Res. 2017;87:201. doi:10.1024/0300-9831/a000516
  3. Nozari S, Fathi Maroufi N, Nouri M, Paytakhti Oskouei M, Shiralizade J, et al. Decreasing serum homocysteine and hypocholesterolemic effects of Bovine lactoferrin in male rat fed with high-cholesterol diet. J Cardiovasc Thorac Res. 2018;10:203. doi:10.15171/jcvtr.2018.35
  4. Nakamura K, Morishita S, Ono T, Murakoshi M, Sugiyama K, et al. Lactoferrin interacts with bile acids and increases fecal cholesterol excretion in rats. Biochem Cell Biol. 2017;95:142. doi:10.1139/bcb-2016-0052
  5. Morishita S, Kawaguchi H, Ono T, Miura N, Murakoshi M, et al. Enteric lactoferrin attenuates the development of high-fat and high-cholesterol diet-induced hypercholesterolemia and atherosclerosis in Microminipigs. Biosci Biotechnol Biochem. 2016;80:295. doi:10.1080/09168451.2015.1091713
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